Frankfurt earned a 2-1 win at home to Marseille to leave Group D wide open and boost their chances of advancing on the final matchday next week.
The win lifted the reigning Europa League champions to seven points, one ahead of Marseille and level with second-placed Sporting Lisbon.
Tottenham are top on eight after drawing 1-1 against the Portuguese side.Daichi Kamada completed a superb passing move to put the hosts in front after three minutes with their first goal in a home game in the competition this season.
Marseille drew level with a Matteo Guendouzi close-range volley in the 22nd minute but their joy lasted only five minutes, as the former Arsenal midfielder turned from hero to villain by losing possession and allowing Mario Gotze to play a perfect one-two with Randal Kolo Muani, who slotted in the winner.
The winner of Frankfurt’s trip to Sporting next week will qualify for the round of 16, while a draw will also do for the Portuguese side.